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the irradiation leads to delayed wound healing and the paradigms that can enhance the healing of irradiated wound will be useful, especially in conditions where wounds are exposed to ionizing radiation before or after surgery.
introduction propranolol, a nonselective β-blocker, exerts an indirect effect on the vasculature by leaving α-adrenergic receptors unopposed, resulting in peripheral vasoconstriction. we have previously shown that propranolol diminishes peripheral blood following burn injury by increasing vascular resistance. the purpose of this study was to investigate whether wound healing and perioperative hemodynamics are affected by propranolol administration in severely burned adults. methods sixty-nine adult patients with burns covering ≥30% of the total body surface area (tbsa) were enrolled in this irb-approved study. patients received standard burn care with (n = 35) or without (control, n = 34) propranolol. propranolol was administered within 48 hours of burns and given throughout hospital discharge to decrease heart rate by approximately 20% from admission levels. wound healing was determined by comparing the time between grafting procedures. blood loss was determined by comparing pre- and postoperative hematocrit while factoring in operative graft area. data were collected between first admission and first discharge. results demographics, burn size, and mortality were comparable in the control and propranolol groups. patients in the propranolol group received an average propranolol dose of 3.3 ± 3.0 mg/kg/day. daily average heart rate over the first 30 days was significantly lower in the propranolol group (p <0.05). the average number of days between skin grafting procedures was also lower in propranolol patients (10 ± 5 days) than in control patients (17 ± 12 days; p = 0.02), indicative of a faster donor site healing time in the propranolol group. packed red blood cell infusion was similar between groups (control 5.3 ± 5.4 units vs. propranolol 4.4 ± 3.1 units, p = 0.89). propranolol was associated with a 5 to 7% improvement in perioperative hematocrit during grafting procedures of 4,000 to 16,000 cm2 compared to control (p = 0.002). conclusions administration of propranolol during the acute hospitalization period diminishes blood loss during skin grafting procedures and markedly improves wound healing in severely burned adults. as burn patients require serial surgical interventions for motor and cosmetic repair, restricting blood loss during operative intervention is optimal.
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significance: rapid recruitment and activation of macrophages may accelerate wound healing. such accelerated healing was observed in wounds and burns of experimental animals treated with α-gal nanoparticles. recent advances: α-gal nanoparticles ...
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backgroundthree phases are often involved in the intricate process of wound healing: inflammatory exudation, cell proliferation, and tissue remodeling. it is...
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researchers set out to determine whether and how gum-derived stem cells play a role in accelerated wound healing. their results, indicating that these cells secrete tiny vesicles packed with signaling proteins, point the way forward for therapeutic strategies that aim to harness the prowess of stem cells to treat delayed wound healing as well as other conditions that involve an overactive inflammatory response, such as autoimmune diseases.
nfed will host a wound healing conference in collaboration with the children's hospital of philadelphia (chop). we are thrilled to share that the national
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biorxiv - the preprint server for biology, operated by cold spring harbor laboratory, a research and educational institution
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timely and effective wound care treatment is critical to patient outcomes and the overall cost of care, so we’ve made a commitment to help. our clinical team works closely with case managers and providers to develop comprehensive care strategies that incorporate innovative products and services to expedite and accelerate wound treatment.
europe pmc is an archive of life sciences journal literature.
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gifts to the children’s fund are unrestricted, meaning the funds are used where the need is greatest. it touches all areas of children’s hospital of philadelphia, and furthers the hospital’s mission. supporting the children’s fund enables our critical work of saving children’s lives. it also ensures that children have access to one of the nation’s best children’s hospitals.
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the marcus institute of integrative health expands jefferson’s integrative medicine, setting the global standard for evidence-based, patient-centered care.
many people find themselves feeling trapped by their past, burdened by memories that seem impossible to escape. trauma can significantly impact our daily lives and self-esteem, making it challenging to function or find joy. one approach that has gained attention for its effectiveness is eye movement
the increase of cell proliferation during early wound healing is thought to be regulated by a decrease of apoptosis. in contrast, the reduction of cellularity during final wound maturation may be controlled by an increase of apoptotic cell death. herein we studied whether p53 is involved in wound healing–associated apoptosis and whether transient inhibition of p53 is effective to improve the early healing process of cutaneous wounds. using intravital microscopic and immunohistochemical techniques in hairless mice, we demonstrated that in vivo inhibition of p53 by pifithrin-α (pft-α; 2.2 mg/kg ip) accelerates early epithelialization and neovascularization of cutaneous wounds by (i) promoting leukocyte recruitment, (ii) increasing cell proliferation, and (iii) reducing apoptotic cell death. we further show that final wound closure with down-regulation of cell proliferation is not inhibited by pft-α treatment, indicating that transient blockade of p53 function does not affect the process of wound maturation. western blot analysis revealed that pft-α lowered nuclear but not cytoplasmic p53, implying that cytoplasmic retention of p53 mediates the antiapoptotic effects of pft-α. furthermore, pft-α significantly increased expression of proliferating cell nuclear antigen protein in whole extracts of cutaneous tissue and caused a rise in proliferation of wild-type, but not mutant, p53-expressing keratinocytes. from our study we conclude that transient inhibition of p53 supports the early cell proliferation required for rapid tissue repair and that this may represent an attractive approach in the treatment of delayed wound healing.
this article delves into the potential of softwave therapy, and its remarkable benefits and applications in the field of soft tissue healing.
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